Transducin ß-like protein 1 controls multiple oncogenic networks in diffuse large B cell lymphoma

ChIP-Seq analysis showed that TBL1 occupancy was not significantly globally affected after treatment with tegavivint supporting the notion that TBL1 functions as an adaptor protein that facilitates the exchange between co-repressor and coactivators Overall design: Chip-seq was performed in two DLBCL cell lines (Riva and Pfeiffer) to assess the genome-wide localization of TBL1 in the presence or absence of tegavivint for 12 hours