Subgroup analyses.

Results of questionnaires and PPS before and at three months follow up in subjects from active and treatment as usual groups. Only statistical analyses using ITT data are presented. ITT: intention to treat; PP: per protocol; TAU: treatment as usual; MDI: major depression inventory; PPS: pressure pain sensitivity; CSS: Clinical stress signs. *) Forty-two participants had MDI≥15 at baseline. Twenty-one were randomized to active and 21 to TAU group. Thirty-six participants, 18 active and 18 controls completed the study. **) Fifty-nine patients had PPS>81 and CSS≥8 at baseline, corresponding to the highest 50% of both PPS and of CSS. Twenty-nine were allocated to active treatment and 30 to TAU, of whom 24 and 26, respectively, completed the study.