Synthesis of Normorphans through an Efficient Intramolecular Carbamoylation of Ketones
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https://figshare.com/articles/dataset/Synthesis_of_Normorphans_through_an_Efficient_Intramolecular_Carbamoylation_of_Ketones/2143120
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资源简介：
An unexpected C–C bond cleavage
was observed in trichloroacetamide-tethered
ketones under amine treatment and exploited to develop a new synthesis
of normophans from 4-amidocyclohexanones. The reaction involves an
unprecedented intramolecular haloform-type reaction of trichloroacetamides
promoted by enamines (generated in situ from ketones) as counter-reagents.
The methodology was applied to the synthesis of compounds embodying
the 6-azabicyclo[3.2.1]octane framework.
创建时间：
2016-02-13
