Gene Expression Profiles Induced by RNA interference on NSD1 Δ5Δ7, and NSD1 Δ19–23 isoforms in Fibroblast Cells I.

NSD1 Δ5Δ7, NSD1 Δ19–23 5’end and canonical NSD1 transcript are involved in cell cycle regulation and in tumoral and neoplastic development. Another NSD1 isoform AT2 target that might mediate the cellular division mechanisms is ARP3 actin-related protein 3 homolog B ACTR3B that may act downstream of the stress fibers and bundle of actin filaments formation Fibroblasts cell obtained from four different healthy donors were screened to confirm the absence of NSD1 mutation