Massively parallel engineering of persistent CAR-Ts [CLASH]
收藏NIAID Data Ecosystem2026-03-14 收录
下载链接：
https://www.ncbi.nlm.nih.gov/sra/SRP384073
下载链接
链接失效反馈官方服务：
资源简介：
To identify immune-related gene perturbations that enhance CAR-T cell persistence in in vitro and in vivo settings, we generated thousands of CAR-T variants using the CLASH platform and evaluated crRNA representation across time in in vitro and in vivo cancer models. Overall design: After genomic DNA was collected from CAR-Ts (either from in vitro or in vivo experiments), a two step PCR was performed to generate a sequenceable guide library. Raw counts were processed using custom bash and R scripts.
创建时间：
2022-12-10
