Loop-Deleted DNA Polymerase Theta Polymerase Domain in Complex with a dsDNA Overhang and an Allosteric Inhibitor

Loop-Deleted DNA Polymerase Theta Polymerase Domain in Complex with a dsDNA Overhang and an Allosteric Inhibitor Descriptor: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, 2-[3-(2-hydroxyethyl)-2-oxoimidazolidin-1-yl]-4,6-bis(trifluoromethyl)phenyl (4-fluorophenyl)(methyl)carbamate, DNA Primer, ... Authors: Fried, W, Chen, X.S. Deposit date: 2024-08-15 Release date: 2025-08-20 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (3.31 Å) Cite: RTx-303, an Orally Bioavailable Pol theta Polymerase Inhibitor That Potentiates PARP Inhibitors in BRCA Mutant Tumors. J.Med.Chem., 68, 2025