Short-term gene expression changes induced by malformin C in NCH421k patient-derived glioblastoma stem-like cells

Malformin C was identified in a fungal extract screen to selectively induce cell death in glioblastoma stem-like cells (GSCs). Gene expression changes were investigated at early time points before cell death was induced in order to gain insight into the mode of action of malformin C in GSCs. Total RNA extracted from NCH421k GSCs incubated with 50 nM malformin C for 2, 4 and 6 hours, or DMSO for 6 hours. 3 biological replicates for each condition were performed.