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Identification off-target mutations following genetic modification by CRISPR/Cas9 in Plasmodium berghei. Plasmodium berghei ANKA

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NIAID Data Ecosystem2026-03-12 收录
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We developed the novel CRISPR/Cas9 system in the rodent malaria parasites Plasmodium berghei. We conducted a genome-wide sequence analysis of the parental line pbcas9 and the mutant parasites after the genetic modification of non-essential gene (imc1i) to investigate whether the off-target mutation was introduced.

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2021-03-10
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