Transcriptional profiling of human malignant mesethelioma cells that have constitutively treated with sialic acid binding lectin from Rana catesbeiana (cSBL). Transcriptional profiling of human malignant mesethelioma cells that have constitutively treated with sialic acid binding lectin from Rana catesbeiana (cSBL)

cSBL is a multifunctional protein that has lectin and ribonuclease activity, and show selective cytotoxicity against many kinds of cancer cells.For further understanding anti-tumor effects of cSBL, we treated cSBL-sensitive malignant mesothelioma H28 cells with cSBL consecutively, and established cSBL-resistant (cSR) cells. We have established 5 resistant clones and using two clones that show higher resistant rates, microarray analysis was performed to identify significant altered gene expression upon cSBL-sensitive and -cSR cell lines. Overall design: The global gene expression analysis using parental (cSBL-sensitive) and cSBL-resistant malignant mesothelioma H28 cell lines.