Variation of the average values of local structural parameters of helices 3, 5, 6, and 7 in the Basins of Figures 2 and 3 with respect to the analogous parameters of the empty receptor.

The parameters are Tilt (Tilt), Rotation (Rot), and Displacement (Disp) and are extracted from the analysis of equilibrated 70 ns-long standard MD trajectories. Concerning rotation angle, negative values correspond to clockwise rotations, positive to anticlockwise. Standard deviations are also reported.