Myelin-Associated Oligodendrocytic Basic Protein-Dependent Myelin Repair Confers the Long-lasting Antidepressant Effect of Ketamine

To examine ketamine's long-lasting effects on gene expression in the brains of mice exhibiting depression-like behaviors, we used spatial transcriptomics (ST) to analyze transcriptomics on the cortices of mice exposed to chronic social defeat stress (CSDS) and treated with ketamine. Overall design: Wild type C57 mice went through CSDS and resilient and susceptible mice were selected by social interaction test. Some susceptible mice were randomly selected and treated with ketamine. the depression-like behaviors were examined by behavioral tests and the brain samples for ST were collected 7 days after ketamine-administration.