Distinct cellular mechanisms underlie anti-CTLA-4 and anti-PD-1 checkpoint blockade

NIAID Data Ecosystem2026-03-12 收录

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肿瘤免疫治疗细胞机制

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE100809 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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2021-07-25

B16 vs Res499 Whole Exome Sequencing

肿瘤免疫微环境

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Interferon-gamma (IFNG) augments immune function yet promotes T cell exhaustion through PDL1. How these opposing effects are integrated to impact immune checkpoint blockade (ICB) is unclear. We show t

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Table S1 from Multiomics Reveals the Immunologic Features and the Immune Checkpoint Blockade Potential of Colorectal Medullary Carcinoma

结直肠癌免疫微环境

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Supplementary Table 1. Total of 1257 samples for IHC and clinical information.

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Paired VDJ and transcriptome single cell sequencing in LMP2 multimer-positive human T cells treated with anti-PD-L1 and anti-TIM3 antibodies.

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单细胞测序

We report the change in gene expression profile paired to clonotype profiling in single cells from LMP2 multimer-positive human T cells generated following weekly stimulations with antigen-pulsed dend

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Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

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Viral persistence is associated with hierarchical antiviral CD8 T cell exhaustion with increased programmed death-1 (PD-1) expression. In HCV persistence, HCV-specific CD8 T cells from the liver (the

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Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma. Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma

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黑色素瘤免疫治疗

Immune checkpoint blockade (ICB) therapy provides remarkable clinical gains, where melanoma is at the forefront of its success. However, only a subset of patients with advanced tumors currently benefi

NIAID Data Ecosystem40

Distinct cellular mechanisms underlie anti-CTLA-4 and anti-PD-1 checkpoint blockade

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