Identification of causal genes about osteoporosis associated with risk loci using DLO Hi-C [ATAC-Seq]

In this project, we use a simple digestion-ligation-only Hi-C (DLO Hi-C) technology, for whole-genome chromosome conformation capture, analysis of genes expression changes and transcriptional regulatory elements involved in BMMSC differentiation. Rely on GWAS data and eQTL analysis, our findings confirmed some previously reported genes that have an effect on OP, such as TIMP-2, MMP-2 and DAAM2, TMEM241 was less reported. Furthermore, our work provide a theoretical basis for the development of OP. Overall design: The bone marrow mesenchymal stem cells (BMMSCs), osteoblasts and adipocytes