Nrf2 overexpression increases risk of high tumor mutation burden in acute myeloid leukemia

We evaluated differentially expressed genes in Nrf2-High/Low group and found that high Nrf2 expression significantly inhibited the DNA MMR pathway in AML. AML patient specimens were divided into two groups either expressing high or low levels of Nrf2 based on qRT-PCR. In order to further understand the molecular mechanism of Nrf2 on the tumor mutation burden rate in AML, We examined transcriptome sequencing in the above patients, removed the unqualified samples, and analyzed the difference of gene expression.