Stachyose Improves the Effects of Berberine on Glucose Metabolism by Regulating Intestinal Microbiota and SCFAs in Spontaneous Type 2 Diabetic KKAy Mice

Diabetes has become a major public health concern because it causes various health problems and its global prevalence has increased in recent decades. BBR has various pharmacological properties and multispectral therapeutic applications, includingdiabetes, hyperlipidemia, and metabolic syndrome. Nevertheless, the use of BBR is limited due to its poor absorption and gastrointestinal adverse effects. Sta, a functional prebiotic, has been shown to improve antioxidants absorption and intestinal microbiota composition and benefit for diabetes. Here, we observe that the combination of BBR and Sta imparts better effects on the maintenance of glycemia and intestinal homeostasis than BBR alone by modulating gut microbiota and SCFAs, thereby providing a novel approach for the treatment of type 2 diabetes mellitus.