Defects in placental syncytiotrophoblast cells are a common cause of developmental heart disease
收藏NIAID Data Ecosystem2026-03-14 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE204859
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E14.5 placentas from three mutant mutant mouse lines (Atp11a, Smg9 and Ssr2) with high co-occurance of placental and heart defects were sequenced. Transcriptional changes associated with ventricular septal defects were characterized. Mutant mouse lines were generated with EUCOMM/KOMP knockout first conditional-ready targeted ES cell resources ((http://www.mousephenotype.org/about-ikmc/eucomm-program/eucomm-targeting-strategies). Gene expression profiling was comapred at E14.5 between wild-type, and heterozygous and homozygous (KO) mutants (6-11 per genotype) in Atp11a, Smg9 and Ssr2 lines (Tm1a- non functional gene strcuture only)
创建时间：
2023-03-27
