Impact of Renal Function and Symptom Burden on Digoxin Efficacy and Safety: A Post-Hoc Subgroup Analysis of the DIG Trial

This dataset accompanies a post-hoc subgroup analysis of the Digitalis Investigation Group (DIG) trial conducted as assignment for Harvard Medical School (GCSRT), here we examined how varying levels of renal function (as measured by serum creatinine) and symptom burden could influence the efficacy and toxicity of digoxin therapy in patients with chronic heart failure. The analysis stratifies patients into three renal 4 function categories and investigates outcomes of all-cause mortality, Number os symptoms, heart failure hospitalization, and suspected digoxin toxicity. This work addresses a significant gap in the original DIG trial’s published subgroup analyses and contributes novel clinical insight on the risk-benefit profile of digoxin in renally impaired patients with low potassium levels and worsened symptomatology.