Overall comparison of classification performance among different techniques.

PUDI is a SVM-based approach that partitions unlabeled genes into multiple levels with different associations to confirmed disease genes. ProDiGe is a bagging method that iteratively chooses random subsets from unlabeled subset and trains multiple classifiers. Smalter's method integrates multiple biological features, such as topological features, sequence-derived features, evolutionary age features. Xu's method employs the KNN classifier to predict disease genes.