IBS BAG

The IBS BAG includes in this proposal IBS teams and external groups from iRTSV/CEA (Grenoble), CEA-Cadarache (St Paul lez Durance) and IRBA (Brétigny-sur-Orge). We study structure-function relationships of proteins emphasizing in human health, biotechnology and methodology. Most of the projects are a continuation of the MX-2329 proposal and can be grouped in different topics as follows: host-pathogen interaction, new drug targets, fundamental cellular mechanisms, membrane proteins, intrinsically disordered proteins, biotechnological applications and methodology. Some of these projects use integrative approaches (X-ray crystallography, SAXS, NMR (and cryo-EM), together with other biophysical studies) with the aim to fully understand the complexity of the biological macromolecular systems on study. Some teams are dedicated to serial crystallography and its developments, for which the ESRF-EBS has become the perfect tool.本提案中的IBS BAG涵盖IBS团队以及来自格勒诺布尔的iRTSV/CEA、圣保罗勒兹迪朗斯的CEA-Cadarache与布雷蒂尼叙尔奥尔日的IRBA等外部合作团队。本团队聚焦蛋白质结构-功能关系研究，研究方向覆盖人类健康、生物技术与研究方法学三大领域。本项目组多数课题为MX-2329提案的延续，可划分为以下多个研究主题：宿主-病原体互作、新型药物靶点、基础细胞机制、膜蛋白、内在无序蛋白（intrinsically disordered proteins）、生物技术应用及研究方法学。部分课题采用整合研究策略，结合X射线晶体学（X-ray crystallography）、小角X射线散射（SAXS）、核磁共振（NMR）、冷冻电镜（cryo-EM）等多种生物物理研究手段，旨在全面解析所研究的生物大分子系统的复杂性。部分团队专注于串行晶体学（serial crystallography）及其技术发展，其中ESRF-EBS已成为该领域的理想研究工具。