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SAXS experiment for fluorophore and LDL association

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ESRF Portal2026-01-01 更新2026-04-23 收录
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A new fluorophore is currently under development for fluorescence-guided surgery. This contrast agent spontaneously accumulated in some tumor types, but almost failed to accumulated in other ones. To understand the tumor accumulation mechanism, we designed a study which indicated a strong association of the contrast agent with lipoproteins and more particularly with low density lipoprotein (LDL). We are now wondering where/how the contrast agent and the LDL interact: is the contrast agent at the interphase with the shell or with the core or the LDL? Is it associated with a specific part of the LDL?

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2026-01-01
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