Synthesis of Functionalized 1H‑Isochromene Derivatives via a Au-Catalyzed Domino Cycloisomerization/Reduction Approach

A Au-catalyzed versatile and efficient access to 1H-isochromenes is reported. The efficiency of the [AuCl2(Pic)] complex (1–5 mol %) was demonstrated and allowed a domino cycloisomerization/reduction reaction process starting from a wide range of functionalized ortho-alkynyl­benz­aldehydes and one example of ortho-alkynyl­pyridinyl­aldehyde. The smooth reaction conditions were amenable to aryl- and alkyl-substituted alkynyl derivatives, as well as functionalized halogen and ether moieties, leading to a chemo- and regioselective 6-endo-cyclization with good to excellent yields.