Summary of the IC50 (nM) values obtained for the antagonist drugs in combinations as indicated, along with their ‘predicted’ ACB scores.
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Values represent the mean IC50 values (n = 3), ± SEM (nM) for each combination of two drugs.Compared IC50s;a dicycloverine/cyclobenzaprine vs dicycloverine/amitriptyline,b dicycloverine/amitriptyline vs amitriptyline/cyclobenzaprine,c dicycloverine/cimetidine vs cyclobenzaprine/cimetidine andd cyclobenzaprine/cimetidine vs amitriptyline/cimetidine.* P ** P *** P ‘Predicted’ ACB score from linear addition of individual drug ACB scores (Table 2).Summary of the IC50 (nM) values obtained for the antagonist drugs in combinations as indicated, along with their ‘predicted’ ACB scores.
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2015-12-03
