A dataset of the effect of BDE-153 on glucose and lipid metabolism in mice

This is a dataset on the effects of BDE-153 on glucose and lipid metabolism in mice. Adult mice were randomly assigned to six different groups (6 mice in each group): low, medium-low, medium, medium-high, high and control group, corresponding to 5, 25, 50, 100 and 200 mg / kg of BDE-153 dose respectively. The control group was given corn oil. Mice in each group were continuously gavaged at a speed of 0.1 ml / 10 g body weight for 4 weeks. At the end of the second week of exposure, mice in each group fasted for 8 hours and underwent intraperitoneal glucose tolerance test (IPGTT). The mRNA and protein expression levels of Leptin, adiponectin, PPARγ and AMPKα were measured after 4 weeks of BDE-153 exposure. At the same time, biochemical indexes were also measured. The histomorphological changes of liver and pancreas were observed. Our results suggest that BDE-153 may interfere with the secretion of adipokines and insulin sensitivity by affecting the expression of PPARγ and AMPKα, which play a key role in glucose and lipid metabolism, leading to the occurrence of glucose and lipid metabolism disorder.