NF-KB Non Canonical

The non-canonical pathway engaged by members of the TNF-like family of cytokines is responsible for the activation of p100/RelB complexes and occurs during the development of lymphoid organs responsible for the generation of B and T lymphocytes. This pathway utilizes an IKK complex that comprises two IKKalpha subunits, but not NEMO. Activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes.