Crystal structure of the first bromodomain (BD1) of human BRD4 bound to NC-II-153
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Crystal structure of the first bromodomain (BD1) of human BRD4 bound to NC-II-153 Descriptor: 1,2-ETHANEDIOL, 2-methyl-4-[3-(2-oxopyrrolidin-1-yl)phenyl]isoquinolin-1(2H)-one, Bromodomain-containing protein 4 Authors: Chan, A, Schonbrunn, E. Deposit date: 2021-05-07 Release date: 2022-08-03 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.19 Å) Cite: Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity. J.Med.Chem., 65, 2022
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2021-05-07
