Kaposi's sarcoma (KS), is an AIDS-associated neoplasm caused by the KS herpesvirus (KSHV/ HHV-8). KSHV-sarcomagenesis is the consequence of oncogenic viral gene expression as well as host genetic and

NIAID Data Ecosystem60

An oncogenic Ezh2 mutation cooperates with particular genetic alterations to induce tumors in mice and redistributes H3K27m3 through the genome [RNA-seq]. Mus musculus

肿瘤表观遗传学

癌症动物模型

B-cell lymphoma and melanoma harbor recurrent mutations in the gene encoding the EZH2 histone methyltransferase, but the carcinogenic role of these mutations is unclear. Here we describe a mouse model

NIAID Data Ecosystem40

Semiconductor based DNA sequencing of histone modification states

组蛋白修饰

肿瘤表观遗传学

The recent development of a semiconductor-based, non-optical DNA sequencing technology promises scalable, low-cost and rapid sequence data production. The technology has previously been applied mainly

NIAID Data Ecosystem60

DNA methylation data from pilocytic astrocytoma tumor samples and normal cerebellum controls. Homo sapiens

肿瘤表观遗传学

发育基因调控

Pilocytic astrocytomas (PA) are the most common brain tumor in pediatric patients and can cause significant morbidity, including chronic neurological deficiencies. They are characterized by activating

NIAID Data Ecosystem60