TOP3B

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]

本基因编码一种DNA拓扑异构酶，该酶在转录过程中控制并改变DNA的拓扑状态。此酶催化单链DNA的瞬时断裂与重新连接，使链间得以相互穿过，从而松弛超螺旋并改变DNA的拓扑结构。该酶与DNA解旋酶SGS1相互作用，并在DNA重组、细胞衰老以及基因组稳定性维持中发挥作用。此基因的低表达可能与乳腺癌患者的较高存活率相关。该基因在第22号染色体上存在假基因。选择性剪接导致多种转录变体。此外，已描述了该基因的其他选择性剪接转录变体，但其全长性质尚不明确。[由RefSeq提供，2013年8月]