Timelapse microscopy dataset - The Mannose Receptor on Sinusoidal Lining Cells Mediates Two-Step Bacterial Clearance in the Human Spleen

In the red pulp of the human spleen, differently to equivalent anatomical sites in other animals, capsulated bac-teria are captured by the CD206 mannose receptor on sinusoidal lining cells and only in a second moment deliv-ered to CD163+ red pulp macrophages. The data deposited represent four 20 min time lapse microscopy videos of primary human spleen cell cultures containing CD163+ macrophages and CD206+ sinusoidal lining cells. The four videos show the two types of human primary cells: 1) without any addition (uninfected and uninhibited control); 2) with Streptococcus pneumoniae (in green) (infected); 3) with S. pneumoniae and mannose (infected and CD206 inhibition); 4) with mannose only (not infected, but CD206 inhibition). Data are supplementary to a submitted manuscript.