KSR2:MEK1 Complex Bound to the Small Molecule APS-2-79
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KSR2:MEK1 Complex Bound to the Small Molecule APS-2-79 Descriptor: 6,7-dimethoxy-~{N}-(2-methyl-4-phenoxy-phenyl)quinazolin-4-amine, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2 Authors: Dhawan, N.S, Scopton, A.P, Dar, A.C. Deposit date: 2016-06-22 Release date: 2016-08-31 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.509 Å) Cite: Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Nature, 537, 2016
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2016-06-22
