DataSheet1_Associations of thyroid hormones with chronic diarrhea and constipation in euthyroid individuals.docx

BackgroundAbnormalities in thyroid function affect bowel health. However, the relationships between thyroid hormone concentrations and the risk of developing chronic diarrhea and constipation remain unclear. Thus, the aim of this study was to investigate the relationships between thyroid hormone concentrations and the risk of developing chronic diarrhea and constipation in euthyroid US adults.MethodsThe data for this population-based study were taken from the National Health and Nutrition Examination Survey (NHANES) 2007–2010 datasets. The relationships between thyroid hormone concentrations and the risk of developing chronic diarrhea and constipation were examined via multivariate regression. Smoothed curve fitting and threshold effects analysis were used to test for nonlinear relationships and inflection points.ResultsThis study involved 4999 participants ranging in age from 20 to 80 years. Multivariate logistic regression analysis revealed a significant positive correlation between FT3 concentrations and the risk of developing chronic diarrhea [1.37 (1.00, 1.88), P=0.049]. Multivariate linear regression analysis revealed a significant positive correlation between FT3 concentrations and the number of bowel movements [0.84 (0.39, 1.28), P

甲状腺功能异常对肠道健康产生显著影响。然而，甲状腺激素浓度与慢性腹泻和便秘发生风险之间的关联尚不明确。因此，本研究旨在探究甲状腺激素浓度与处于正常甲状腺功能状态的美国成人慢性腹泻和便秘发生风险之间的关系。研究方法：本基于人群的研究数据来源于2007-2010年的国家健康与营养检查调查（NHANES）数据集。通过多元回归分析考察了甲状腺激素浓度与慢性腹泻和便秘发生风险之间的关联。利用平滑曲线拟合和阈值效应分析来检验非线性关系和拐点。研究结果：本研究纳入了4999名年龄介于20至80岁之间的参与者。多元逻辑回归分析显示，FT3浓度与慢性腹泻发生风险之间存在显著的正相关关系[1.37 (1.00, 1.88)，P=0.049]。多元线性回归分析揭示了FT3浓度与排便次数之间存在显著的正相关关系[0.84 (0.39, 1.28)，P