Catalytic Asymmetric Synthesis of Cyclic Sulfamides from Conjugated Dienes

This paper describes the catalytic asymmetric diamination of alkyl dienes using N,N′-di-tert-butylthiadiaziridine 1,1-dioxide in the presence of Pd(0) and a chiral phosphoramidite ligand to give cyclic sulfamides in high yield and high ee. The diamination is also amenable to gram scale.

本文详细阐述了在钯(0)催化剂和手性膦酰胺配体存在下，利用N,N'-二叔丁基噻二唑啉-1,1-二氧化物对烷基二烯进行催化非对称双官能化的过程，以实现高收率和高ee值合成环状磺酰胺。此外，该双官能化反应亦适用于克级规模生产。