Evaluating lipid-driven insulin resistance via TyG index in breast cancer patients: Toward effective secondary prevention

Breast cancer is the most commonly diagnosed malignancy worldwide. Insulin resistance (IR) plays a key role in its progression by activating oncogenic signaling pathways. The triglyceride-glucose (TyG) index is a validated, cost-effective surrogate marker for IR. This study aims to evaluate the prevalence of IR in female breast cancer patients using the TyG index and to identify lipid parameters associated with increased IR, thereby supporting strategies for secondary prevention.
A cross-sectional study was conducted among non-diabetic, histopathologically confirmed female breast cancer patients. Demographic data, lipid profiles, and fasting glucose levels were collected. Participants were stratified into high-risk (TyG ≥ 8.87) and low-risk (TyG < 8.87) groups based on their TyG index. Logistic regression analysis was performed to identify significant predictors of elevated TyG index.
Among 122 patients, 44.3% demonstrated elevated insulin resistance. Triglycerides (TG), total choles..., , # Data from: Evaluating lipid-driven insulin resistance via TyG index in breast cancer patients: Toward effective secondary prevention

Dataset DOI: [10.5061/dryad.kd51c5bjn](10.5061/dryad.kd51c5bjn)

## Description of the data and file structure

This dataset contains clinical, biochemical, and lifestyle parameters relevant to cardiometabolic health. The variables are structured in a tabular format, where each row represents a single individual and each column corresponds to a clinical, biochemical, or derived parameter. The dataset is intended for research purposes in the fields of cardiovascular disease risk assessment, metabolic health, epidemiology, and machine learning–based health prediction.

## Variables and Definitions

#### File: data.csv

1. **Age (years)** – Chronological age of the participant.
2. **Cholesterol (mg/dL)** – Total serum cholesterol level.
3. **Triglyceride (mg/dL)** – Serum triglyceride concentration.
4. **HDL (mg/dL)** – High-density lipoprotein cholesterol..., We have obtained the explicit consent from the participants to publish the de-identified data in the public domain by taking only 3 indirect identifiers and removed the personal details of the participants.