Comparative analysis of the global expression of genes involved in the evolution of patients to post-Chikungunya Chronic Inflammatory Joint Disease

Infection with the Chikungunya virus (CHIKV) often results lead in a chronic joint condition known as Post-Chikungunya Chronic Inflammatory Joint Disease (pCHIKV-CIJD). This condition not only disrupts individuals' everyday life, but also contributes to increased healthcare expenditure. Here, using system biology approaches we investigated the molecular mechanisms underlying pCHIKV-CIJD development by analyzing RNA transcripts, including small RNAs, of whole blood from CHIKV infected patients.