Crude and adjusted rate ratios of lung, colorectal, prostate and breast cancer associated with antihypertensive agents relative to diuretic and/or beta-blocker use.

Abbreviations: RR, rate ratio; CI, confidence interval; ARB, angiotensin receptor blocker; ACEI, angiotensin-converting enzyme inhibitor; CCB, calcium channel blocker.
*Cases and controls were matched on year of birth, year of cohort entry, sex, prevalent user status, and duration of follow-up.
†All models were adjusted for excessive alcohol use, body mass index, smoking, diabetes, previous cancer, and ever of aspirin, statins, and NSAIDs. In addition, cholecystectomy, inflammatory bowel disease and history of polyps for colorectal cancer; benign prostatic hyperplasia, 5-alpha reductase inhibitors, and number of PSA tests for prostate cancer; oophorectomy, use of hormone replacement therapy, and prior use of oral contraceptives for breast cancer.
‡Defined prescriptions of both agents overlapping each other for at least one day.