A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes. Macaca fascicularis

We constructed the first single-nucleus transcriptomic landscape of primate liver aging, and address cell-type-specific gene expression fluctuation especially in hepatocytes spanning three zonations, and aberrant cell-cell interaction, especially between hepatocytes and their niche cells in aged liver.