Fitness effects of inherited SNVs.

For each genomic annotation (rows), the table shows the number of variants and derived alleles (number of heterozygous genotypes + 2 * number of homozygous genotypes) carried by NA06985, NA06986, NA06994, HG02234, HG02237, and HG02240 (averaging over the 6 individuals). Mean fitness burden is computed as described in the Methods, by weighing each genotype by s for the relevant genotype and functional category. The mean s values represent the mean of the distribution of the segregating variants in the SLiM simulation. (XLSX)