Non- microdissected tumors with intertumoral heterogeneity indicated by gain and/or loss of molecular alterations during tumor progression.

Surgery: designates the individual center of tumor operation:
NL: Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
B: Charité Universitätsmedizin, Berlin, Germany.
HD: University Hospital, Heidelberg, Germany.
#: number of all tumors analyzed.
n (P): number of individual tumor pairs.
P/R: identifies primary (P) and recurrent (R) tumor of each tumor pair.
ID: internal tumor ID.
Tissue: abbreviation of diagnosis based on histology.
het.: retained heterozygosity.
LOH: loss of heterozygosity.
pLOH: partial loss of heterozygosity.
mut: mutated TP53/IDH1.
wt: wild type TP53/IDH1.
n.d.: not determined.

Bold characters in column:
n (P): highlight every second tumor pair of individual patients.
P/R: highlight every primary tumor of individual patients.
TP53 in detail: highlight the position of individual base exchanges in the affected codon of the TP53- gene.
In all remaining columns bold characters highlight tumor pairs with novel molecular alterations during tumor progression.

Bold italic characters:
Highlight tumor pairs in which molecular alterations of the primary tumor are lost during tumor progression.