Impaired neutrophil-mediated cell death drives Ewing Sarcoma in the background of Down Syndrome

Ewing Sarcoma (EWS) has been reported in few children with Down Syndrome (DS). A detailed assessment of this solid tumor in DS patients was still missing. The current work aims at characterising a chemo-resistant mediastinal EWS in a 2-year-old DS child, the youngest ever reported case, by exploiting sequencing approaches. Both Whole Exome Sequencing and RNA Sequencing data were used.