Gold(I)-Catalyzed Highly Diastereo- and Enantioselective Constructions of Bicyclo[3.2.1]oct-6-ene Frameworks via (4 + 3)-Cycloadditions
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https://figshare.com/articles/dataset/Gold_I_-Catalyzed_Highly_Diastereo-_and_Enantioselective_Constructions_of_Bicyclo_3_2_1_oct-6-ene_Frameworks_via_4_3_-Cycloadditions/17296974
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资源简介：
A one-pot
construction of bicyclo[3.2.1]oct-6-ene frameworks involves
gold-catalyzed (4 + 3)-cycloadditions between 2-(1-alkynyl)-2-alken-1-ones
and substituted cyclopentadienes; diastereoselectivity (dr >25:1)
and enantioselectivity (up to 99.9% ee) are achieved with a chiral
gold catalyst. Our DFT calculations suggest a three-step ionic mechanism
for the cycloadditions of gold-containing 1,3-dipoles with cyclopentadienes,
in which an exo-spatial arrangement is preferable.
创建时间：
2021-12-20
