Parameter values.

(A) Parameter values that were assessed in the context of the simulation model. The age-specific baseline rate of acquisition of pneumococcal carriage, β(a), was considered in 3 age groups as a stepwise function with values β1, β2 and β3. There are 6 mixing group-specific parameters (d1–d6) in the model, corresponding to family, 2 different types of day care groups (children 0.5–2 years of age, and children 3–6 years of age), school (children 7–17 years of age), neighbourhood, and the general population. Five of these (d1–d5) were calibrated. A range of the design grid (in parentheses) is given that covers values corresponding to the 9,000 simulation runs in the calibration process. The values of the two competition parameters were searched before the final calibration phase so that their ratio (θ2/θ1 = 0.93) reproduces the serotype distribution. For more details, see File S2. (B) Parameter values that were given literature values.