Discovery of a KRAS G12V Inhibitor in vivo Tool Compound starting from an HSQC-NMR based Fragment Hit
收藏Protein Data Bank Japan2023-10-25 更新2026-03-28 收录
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Discovery of a KRAS G12V Inhibitor in vivo Tool Compound starting from an HSQC-NMR based Fragment Hit Descriptor: 1H-benzimidazol-2-ylmethanethiol, 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile, GTPase KRas, ... Authors: Phan, J, Fesik, S.W. Deposit date: 2022-03-08 Release date: 2022-11-09 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.702 Å) Cite: Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS G12C Inhibitor. J.Med.Chem., 65, 2022
创建时间：
2022-03-08
