Discovery of a Selective and Potent Inhibitor of Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2 (MNK1/2) Utilizing Structure-Based Drug Design
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https://figshare.com/articles/dataset/Discovery_of_a_Selective_and_Potent_Inhibitor_of_Mitogen_Activated_Protein_Kinase_Interacting_Kinases_1_and_2_MNK1_2_Utilizing_Structure_Based_Drug_Design/3126685
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The discovery of a highly potent and selective small molecule inhibitor 9 for in vitro target validation of MNK1/2 kinases is described. The aminopyrazine benzimidazole series was derived from an HTS hit and optimized by utilization of a docking model, conformation analysis, and binding pocket comparison against antitargets.
创建时间：
2016-04-14
