Oleanane-Type Triterpenoids from the Leaves and Twigs of Fatsia polycarpa

Seven new oleanane-type triterpenoids (1–7), named fatsicarpains A–G, and the known compounds 3α-hydroxyolean-11,13(18)-dien-28-oic acid (8) and 3α-hydroxyolean-11-en-28,13β-olide (9) were isolated from the leaves and twigs of Fatsia polycarpa on the basis of bioassay-guided fractionation. The structures of compounds 1–7 were elucidated through spectroscopic analyses and single-crystal X-ray crystallography of 1, 8, and 9. Cytotoxicity against HepG2 2.2.15 and AGS cells and antihepatitis B virus (HBV) and antibacterial activities of 1–9 were also evaluated in vitro.

七种新的oleanane型三萜类化合物（1-7），命名为faticarpains A-G，以及已知的化合物3α-羟基olean-11,13(18)-二烯-28-酸（8）和3α-羟基olean-11-烯-28,13β-内酯（9），均从Fatsia polycarpa的叶和枝条中通过生物活性导向的分级分离得到。化合物1-7的结构通过光谱分析以及1、8和9的单晶X射线晶体学解析得以阐明。此外，在体外还评估了1-9对HepG2 2.2.15和AGS细胞的细胞毒性、抗乙型肝炎病毒（HBV）活性和抗菌活性。