Conserved protein folds underpin the diversification of secreted proteins in a fungal pathogen

This repository contains the data for the work: Conserved protein folds underpin the diversification of secreted proteins in a fungal pathogen(Thaís C. S. Dal’Sasso, Eva H. Stukenbrock)Datasets: Metadata: Sequence- and structure-based annotations for the secretome of Z. passerinii Zpa796. Network: All-vs-all pairwise TM-scores and the resulting network for the secretome of Z. passerinii Zpa796. Physicochemical_properties: Physicochemical properties computed with AMAPEC using both sequence and structural information from the secretome of Z. passerinii Zpa796. Protein_structures: All protein files generated or used in the study. Protein_Data_Bank: Crystallized structures and fungal protein sequences downloaded from the PDB (https://www.rcsb.org/), plus AlphaFold2 and ESMFold predictions for the corresponding proteins. Includes tables of all-vs-all pairwise TM-scores for the crystallized structures and their structural predictions. Structural_alignments: Pairwise alignments of Z. passerinii Zpa796 putative effectors and their homologs in Z. tritici IPO323. Zpa796: Protein structures predicted for the Z. passerinii Zpa796 secretome using AlphaFold2 and ESMFold.