RNA-seq comprehensive analysis reveals the long non-coding RNA expression profile and co-expressed mRNA in adult degenerative scoliosis. RNA-seq comprehensive analysis reveals the long non-coding RNA expression profile and co-expressed mRNA in adult degenerative scoliosis

Owing to the intensification of the aging process worldwide, the prevalence of adult degenerative scoliosis (ADS) is increasing at an alarming rate. However, genomic research related to the etiology of ADS is rarely reported worldwide. Since long non-coding RNAs (lncRNAs) play a pivotal role in the progression of human diseases, this study aimed to investigate ADS-associated messenger RNAs (mRNAs) and lncRNAs by RNA sequencing (RNA-seq), as well as performed comprehensive bioinformatics analysis. Overall design: Six whole blood (WB) samples were obtained from 3 ADS patients and 3 non-degenerative lumbar adult volunteers for RNA-seq exploration to construct differential mRNA and lncRNA expression profiles.