Cellular and molecular mechanisms underlying granulosa cell tumor induced by constitutively activated TGFB signaling

Mice harboring constitutively activated TGFβ signaling (TGFBR1-CA) develop ovarian GCTs that phenocopy the hormonal and several molecular characteristics of human GCTs. The goal of this study is to determine molecular alterations in the ovary upon TGFβ signaling activation. We performed Next-generation sequencing (NGS) analysis of ovaries from TGFBR1-CA mice and age-matched controls during tumor formation Ovarian mRNA profiles of 30-day old TGFBR1-CA mice and control mice