Top predicted ASD risk genes from the TADA analysis of combined ASD data (de novo, inherited and case-control).

The column shows the p-values using the De Novo Test from the de novo LoF mutations alone. The column shows the p-values from the TADA test using all LoF data. The column shows the p-values from the TADA test using both LoF and Mis3 data. The star symbols mark the double-hit genes that were reported in earlier publications. C1orf95 also has q-value[40]. While the AASC sample is of European ancestry, a portion of it, largely from Portugal, carries some sub-Saharan alleles [7]. Thus, this signal is likely due to population substructure. Similarly, the 3 LoF variants seen in S100G are copies of a splice variant that is common in African populations, so this result should be viewed with caution.