Transcription profiling of mouse Notch1 deficient in hair follicles

Notch1 deficient hair matrix keratinocytes have lower mitotic rates, resulting in smaller follicles with fewer cells. In addition, the ratio of melanocytes to keratinocytes is greatly reduced. Microarray was performed to study downstream mechanism of Notch1-deficiency Experiment Overall Design: Microarray was first performed using HF_emN1-1 and HF_anN1-1 samples. Later, HF_emN1-2, HF_anN1-2, HF_WT-1, and HF_WT-2 were used to perform another set of microarray. anN1s and WTs were used as wild-type controls.