Antidepressant treatment with fluoxetine during pregnancy and lactation modulates the gut microbiome and metabolome in a rat model relevant to depression

Data and figures are provided on the effects of fluoxetine, a selective serotin reuptake inhibitor (SSRI) antidepressant, on the gut microbiome and metabolome in a rat model to better understand the effect of this drug on women during gestation and lactation. Throughout pregnancy and lactation, female rats received the SSRI fluoxetine or vehicle. High resolution 16S ribosomal RNA marker gene sequencing and targeted metabolic analysis were used to assess the fecal microbiome and metabolic availability, respectively.

本数据集提供了氟西汀（一种选择性5-羟色胺再摄取抑制剂，简称SSRI）抗抑郁药对大鼠肠道菌群和代谢组的效应数据，旨在深入探究该药物在妊娠和哺乳期女性中的影响。在整个妊娠及哺乳期间，雌性大鼠分别接受了SSRI氟西汀或对照药物。通过高分辨率16S核糖体RNA标记基因测序和靶向代谢分析，对粪便微生物群和代谢可用性进行了评估。