A senescent liver is rejuvenated in a young systemic environment: A study based on comparison of chronological and biological ages

Though the liver plays central roles in metabolism, the pivotal biological events throughout its aging are still unknown, resulting in ambiguity as to whether liver senescence could be reversed. To establish a criterion for liver-aging evaluation, dynamic hepatic biological features, including liver function, histology, transcriptional profile and protein expression, were screened in a cohort of Lewis rats at sequential chronological ages from 3 months to 24 months. G1 (S3M-1, S3M-2, S3M-3), G2 (S9M-1, S9M-2, S9M-3), G3 (S12M-2, S12M-3, S12M-4), G4 (S18M-1, S18M-3, S18M-4) and G5 (S24M-1, S24M-2, S24M-3,S24M-4)